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That caveat established, the preclinical signal is unusually consistent across independent research groups and across a wide range of injury models, which is why the scientific conversation around BPC-157 continues to accelerate

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As a consequence, the hydrolysis of extracellular ATP and accumulation of adenosine are favored, and signaling via adenosine receptors promotes deoxygenation of sickle hemoglobin and in turn (HbS) polymerization and RBC sickling

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