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Considering that heme oxygenase-1 (HO-1) gene KO and treatment with zinc protoporphyrin IX (a HO-1 inhibitor) reduced Fe + levels and ROS-mediated LPO in PR cells, it has been proposed that HO-1 is a critical modulator of PR ferroptosis induced by atRAL (108)

Transplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs

Oct 5 2020;884:173368

HbC heterozygotes (HbAC) are typically asymptomatic, while HbC homozygotes (HbCC) experience mild hemolytic anemia due to decreased RBCs solubility and crystal formation [33]