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Zhou, Y.C

Liu W, Li X, Wong YS, Zheng W, Zhang Y, Cao W, et al

b) Phase I reactions include oxidation, reduction, and hydrolysis

Also known as a Jarisch Herxheimer reaction, this type of reaction was discovered when two dermatologists, Adolph Jarisch and Karl Herxheimer found that some individuals undergoing an antibiotic regimen for syphilis started to experience a skin reaction in response (1)