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Hypomethylation at this site was associated with an upregulation in BACE1 gene products and corresponded to an increase in amyloid plaque load, neurofibrillary tangle density, and a higher severity of cognitive symptoms

In contrast, the modulatory pathway from Purkinje cells in Crus I to VTA neuronsmediated via the dentate nucleusis more clearly established (68, 75)

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Hence, they might respond differently to certain medications

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