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When GPX4 is removed from mice models, adults lost body weight and died within 2 weeks due to mitochondrial damage, decreased electron transport chain activity (Yoo et al., 2012)

Using a 10% or more increase in whole body oxygen con-sumption as their endpoint, 13 patients who received NAC were considered responders, and 16 were considered nonresponders

In the quest for novel metabolic targets, approaches such as CRISPRCas9-mediated synthetic lethality screens targeting metabolic genes offer a pathway for identifying specific metabolic targets of interest, particularly in vivo

[DOI] [PubMed] [Google Scholar] Dowty ME, Lin J, Ryder TF, Wang W, Walker GS, Vaz A, Chan GL, Krishnaswami S, and Prakash C (2014) The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans

apart from Mischley et al