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Morning administration is generally preferred as it supports daytime energy metabolism and fat oxidation

The timeline depends on the condition being addressed, the administration route, dosing consistency, and individual response factors

Antibiotics : Some antibiotics like tetracycline and chloramphenicol may interfere with the action of B vitamins, particularly vitamin B12 (cyanocobalamin)

It is also not known whether vitamin B 12 can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity

However, for those with inactive disease it may be reasonable to stop at the start of the third trimester, in line with peak foetal development[1]