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Notably, preclinical studies have shown that AAV- NaV1 treatment reduces mortality by 40% in female Scn1a+/ mice and ameliorates hyperactivity/anxiety-like behaviors in males, with this sex-dependent efficacy linked to baseline differences in GABAergic neuronal activity between sexes

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It has also been shown that carnitine administration at a dosage of 2 g/day for 12 months to subjects with T2DM resulted in a significant improvement in homeostatic model assessment-insulin resistance (HOMA-IR) (Derosa et al., 2011[12])