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PLoS ONE 2014 , 9 , e107895

Oxidative stress-induced NLRP3 inflammasome activation (via TXNIP axis) and mitochondrial dysfunction critically mediates Caspase-1-dependent IL-1 maturation, exacerbating renal damage including mesangial injury, podocyte apoptosis, and tubulointerstitial fibrosis (84).Conversely, gut microbiota-derived SCFAs exert protective effects through multiple mechanisms: direct inhibition of TLR4 signaling (e.g., by attenuating MyD88/NF-B phosphorylation)

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JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition