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The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]

On the other hand, semaglutide is a GLP-1 receptor agonist that suppresses appetite and body weight in clinical trials

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GH-class peptides like CJC-1295/ipamorelin and tesamorelin promote lipolysis through hormone-sensitive lipase activation a mechanism that depends on adequate cellular energy machinery to oxidize the mobilized fatty acids