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The whole blood used in our experiments was not neutrophil enriched, in contrast to the local accumulation of high amounts of neutrophils in osteomyelitis which are recruited to the site of infection

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The overall cumulative dose of DOX at the end of the 4-week period was 32 mg/kg, which is the human equivalent dose of 96 mg/m 2

In conclusion, the intricate interplay between metabolic diseases and protein homeostasis underscores the pivotal role of proteostasis networks, including the UPS, autophagy, and the UPR, in the pathogenesis of conditions such as obesity, T2DM, and MASLD (Fig