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For example, unrestricted ketogenic diets have been shown to increase mortality in mice, and supplementing the OHB precursor 1,3-butanediol has been shown to increase middle-aged mortality in normal mice but extend lifespan in aged mice (Tomita et al

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Lipid peroxidation of the mitochondrial membrane produces toxic molecules such as 4-hydroxynonenal and malondialdehyde, which in turn disturb mitochondrial membrane fluidity.108109 The impaired mitochondrial membrane leads to dysregulation in ionic balances and excessive intracellular calcium influx, which consequently causes neuronal death and impairs synaptic plasticity.110111112 NEUROPROTECTIVE AND ANTI-INFLAMMATORY THERAPY IN SCHIZOPHRENIA Randomized controlled trials have investigated the efficacy of adjuvant COX-2 inhibitor on antipsychotics treatment in schizophrenia