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Heffernan, Jiang, Thorburn, and Ng reported in the American Journal of Physiology that oral administration of AOD9401 to ob/ob mice was associated with reduced body-weight gain, altered adipose lipogenic and lipolytic activity, and acute changes in energy expenditure, evidence that a growth-hormone C-terminal fragment could act after oral delivery in a rodent model [3]

Abstract EP1030 Richardson P, San Miguel J, Moreau P, Hajek R, Dimopoulos M, Laubach J et al (2018) Interpreting clinical trial data in multiple myeloma: translating findings to the real-world setting

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Each additional amino acid residue requires an additional coupling step in solid-phase synthesis, adding reagent cost and cumulative yield loss

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