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10.1093/hmg/ddi261 125 SafaiN.SuvitaivalT.AliA.SpgelP.Al-MajdoubM.CarstensenB.et al (2018)

Cancer-associated IDH1 promotes growth and resistance to targeted therapies in the absence of mutation

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This structural modification significantly reduces its affinity for IGF binding proteins (IGFBPs), increases the free concentration, and enhances its biological activity by more than three times compared to natural IGF-1

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