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In addition to impact DNA structure and function, the principal actin mechanism of platinum is to generate ROS to lead to cell death [20, 21]

Wilson, D.P

CuNPs were found to stimulate oxidative stress in tumor tissue homogenates as detected by MDA elevation and reduce antioxidant state as represented by a reduction in GSH and CAT activity compared to untreated tumor tissue, which eventually results in tumor cell death as detected in histopathological analysis that showed degenerative changes in the form of vacuolation of neoplastic cells in the tumor tissue of CuNPs/EC treated mice

Conversely, the B-cell compartment demonstrates the most protracted recovery course among all major lymphocyte subsets, often failing to reconstitute fully until years after allo-HSCT (45, 46)

Unlike plasma, CSF is not separated from the brain by the bloodbrain barrier