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Overall, melatonin's ability to affect multiple pathways involved in the pathophysiology of FM makes it a promising adjunctive treatment for this chronic pain syndrome [66, 67]

doi: 10.1007/s00223-018-0490-5 135

Inhibition of key regulators of 2D cell locomotion such as actin polymerization, cell-matrix adhesion, and myosin contractility fail to block confined migration of MDA-MB-231 breast cancer cells [153], suggesting the existence of alternative mechanisms facilitating their movement

Then tetrahydrofolate is catalyzed by serine hydroxy methyltransferase to produce 5,10-methylenetetrahydrofolate (5,10-MTHF)