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In HCC, gut microbiota dysbiosis inhibits the cGAS-STING-IFN-I pathway, impairing the antigen presentation function of dendritic cells and weakening the activation and function of effector CD8 + T cells, leading to primary resistance to radiotherapy or ICI

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GPs plays a crucial role in regular screening for these cancers

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Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, Nezhat CN, Kempson R, Lessey BA, Nayak NR, Giudice LC (2006) Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women