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FIGURE 4 3.1 Modulation of inflammatory signaling pathways 3.1.1 Inhibition of nuclear Factor- B (NF- B) pathway Glycyrrhizin exerts anti-inflammatory effects and directly protects hepatocytes by regulating genes such as interleukin-4 (IL-4), fibroblast growth factor 10 (FGF10), inhibiting Inhibitor of kappa B (I B) phosphorylation and p65 nuclear translocation to suppress NF- B activation in hepatocytes, thereby reducing the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) (Hsiang et al., 2015

Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

Support for Lean Body Composition By supporting fat metabolism without targeting muscle tissue, 5-Amino-1MQ may help preserve lean mass during fat reduction efforts

Molecular Profile Molecular Weight 403.93 Da (free) / 467.04 Da (Cu complex) Sequence GHK (Gly-His-Lys, 3 amino acids) Purity Spec 98% by HPLC Storage Store lyophilized at 20C

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