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Practical relevance over theoretical sophistication: While other systems may incorporate more features, they often suffer from increased complexity, potential immunogenicity, and difficulty in clinical translation

Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape

MDHA is either directly reduced back to AsA by MDHAR or undergoes non-enzymatic disproportionation to AsA and dehydroascorbate (DHA)

These associations further support the hypothesis of genetic susceptibility as a predisposing factor for PBC

Red-flag symptoms such as severe abdominal pain, persistent vomiting, or jaundice require immediate cessation and urgent medical attention