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This is often caused by increased toxins due to the kidneys decreased function

Rich History of Traditional Medicine UsesBerberine is naturally found in the stems, bark and roots of plants with rich herbal medicine traditions

In infectious disease, the upregulation of the expression of protein S6 kinase 2 (S6K2), which is linked to lactylation, enhances susceptibility to white spot syndrome virus in shrimp, indicating the role of lactylation in the pathogen response [140]