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Antimicrob Agents Chemother 63(2):e00904-e918 Franco J, Sardi F, Szilgyi L, Kvr KE, Fehr K, Comini MA (2017) Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes

Direct in vitro comparisons of these mAbs showed comparable antibody-dependent cell-mediated toxicity (ADCC) and binding affinities, but remarkable differences in the ability to induce direct apoptosis, to induce complement-mediated cytotoxicity (CDC), to inhibit enzymatic activities, and to induce antibody-dependent cell-mediated phagocytosis (ADCP)(Figure 2 and Table 12)[41-42]

The activity of monoamine oxidase, the enzymes that break down monoamines such as DA, 5-HT and NE, is influenced by ROS and in turn can increase ROS production in mitochondria

with pilocarpine at a dose of 4.5 mg/kg bodyweight (200 l), or 0.9% saline as a vehicle control