melanotic sarcoma begins with Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features Special Emphasis on Dermatoscopic Findings | American Journal of Clinical Dermatology Melanoma - Symptoms, Staging &

Metabolic re-wiring that limits the malate-aspartate shuttle and mitochondrial substrate oxidation, and promotes aerobic glycolysis, the re-oxidation of NADH by MDH1, folate cycle NADPH production, and pentose phosphate supply by the non-oxidative PPP may thus constitute a successful strategy for minimizing ROS production and supporting high proliferation rates in oxygen-rich environments

Biochim Biophys Acta - Bioenerg 1863:148567

however, the difference between the two groups was not significant

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