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To determine whether the macrophage-derived EVs possessed the capacity to sequester and remove iron, EVs were incubated with different samples including myocardium lysate, cardiomyocytes lysate, serum and cardiomyocyte culture medium (Fig

doi: 10.1186/s12951-020-00693-4

Exogenous ROS is mainly caused by radiation and other conditions, while endogenous ROS is mainly produced by mitochondria and endoplasmic reticulum 57,58