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Localised iron overload has been associated with several neurodegenerative diseases (i.e., Alzheimers disease and Parkinsons disease), based on measurements of elevated brain iron, demonstrated through magnetic resonance imaging (MRI) imaging [23-25] , ferritin in cerebrospinal fluid (CSF) [26,27] , and postmortem analyses [28-30]

Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges

Essential oils are found only in 10% of plant kingdoms

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Enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) play crucial roles in detoxifying ROS and maintaining redox balance within melanocytes 46