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Furthermore, since AOD 9604 therapy does not significantly impact growth and only slightly affects hormone pathways, it is safe to use on a long-term basis with continued medical supervision

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In addition, the SOCS gene is activated by GH signaling and works as a short intracellular negative feedback loop which rapidly down-regulate GHR activity by internalization and receptor ubiquitinoylation resulting in lysosomal and proteasomal degradation (101)