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Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)

brassicicola ( AbGst1 ) was significantly enhanced by isothiocyanates, heavy metals and 1-chloro-2,4-dinitrobenzene, but the superoxide-generating menadione and paraquat were inefficient

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