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Disorders of energy metabolism are manifested as decreased adenosine monophosphate-activated protein kinase (AMPK) activity and excessive activation of mechanistic target of rapamycin (mTOR), which lead to the downregulation of key energy metabolism factors peroxisome proliferator-activated receptor alpha/proliferator-activated receptor gamma coactivator 1-alpha (PPAR-/PGC-1), causing mitochondrial dysfunction and lipid accumulation (Zhou S