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Recent studies have identified ferroptosis as a contributing factor to keratinocyte dysfunction and inflammation, highlighting the roles of lipid peroxidation, iron dysregulation, and ROS accumulation (189)

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In this process, the appearance of platelet-activating factor (PAF) and PAF-like phospholipids (PAF-Lpls) leads to cell membrane instability, which in turn leads to ferroptosis induced by lipid peroxidation

These authors also established that the combination of APR-246 with different compounds and strategies inducing ferroptosis (pharmacological compounds, or genetic inactivation of SLC7A11 or GPX4) had a synergistic effect on the promotion of AML cell death, both in vitro and in vivo

Some research suggests DSIP may enhance GABAergic inhibitory neurotransmission, which would be consistent with its sleep-promoting and anxiolytic properties, as GABA is the principal inhibitory neurotransmitter in the central nervous system and many sleep medications work by enhancing GABAergic function