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by Jack Norris, RD Contents Introduction Brief History of B12 Recommendations for Vegans Government Recommendations Cyanocobalamin Absorption Vegan Health B12 Recommendations Appendix A

Areas Without Adequate Human Evidence Cardiovascular safety Neurological and psychiatric effects Liver and kidney safety Effects on blood glucose in humans Effects on methylation pathways Genotoxicity Carcinogenicity Reproductive and developmental toxicity Use during pregnancy or breastfeeding Interactions with prescription medicines Interactions with supplements or research compounds Long-term exposure Product-Quality Risks Incorrect quinolinium compound Wrong substitution position Incorrect counterion Incorrect active-content calculation Residual starting materials Residual solvents Degradation products Heavy-metal or inorganic contamination Mismatched certificate of analysis Uncontrolled storage and transport Absence of published harm is not proof of safety A compound without routine regulated human exposure may generate very few formal safety reports simply because there is no organised pharmacovigilance system

Synergistic compounds working through different mechanisms can make each component more effective

Step 1: Wash your hands and gather your materials

Potential benefits of ingredients include: Potential benefits of ingredients include: Biotin: As the beauty nutrient, biotin stimulates keratin production for healthy, faster-growing hair and nails and promotes the health of your skins membrane for an all-natural glow