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(2.1) Recommended daily dosage is based on patient's actual weight (2.2) Less than 1 kg: The daily dose is 1.5 mL 1 kg to 3 kg: The daily dose is 3.25 mL 3 kg or more: The daily dose is 5 mL One daily dose of the reconstituted solution (1.5 mL, 3.25 mL or 5 mL) is then added directly to the intravenous fluid (2.2,2.3) See Full Prescribing Information for reconstitution instructions (2.3) Monitor blood vitamin concentrations (2.4) See Full Prescribing Information for drug incompatibilities (2.5) Dosage Forms and Strengths Contraindications Warnings and Precautions Risk of Aluminum Toxicity: Aluminum may reach toxic levels with prolonged administration

doi: 10.1007/978-3-031-58572-2_9 480 HarperAVijayakumarVOuwehandACTer HaarJObisDEspadalerJet al

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Challenges Due to the lack of specific DHFR activators, there are no clinical studies that examined the possibility of stimulating its activity to increase NO availability

Experimental models frequently employ the natural neurotoxin kainic acid to trigger excitotoxic neuronal death, providing a well-established paradigm for studying neurodegeneration [98]