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doi: 10.3109/10715762.2013.778403 70 WangJFieldsJZhaoCLangerJThimmulappaRKKenslerTWet al

This period establishes the gene expression changes that drive collagen synthesis, inflammation reduction, and tissue remodeling

Notably, IL-6 not only modulates hepcidin to affect the release of stored iron from ATMs and intestinal absorption, but also reduces transferrin expression and aggravates iron accumulation by promoting hepcidin production

The findings of the present study about regulation mechanisms of CHAC1 are informative for development of therapeutic strategies through regulation of ferroptosis in IRI