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The accumulation of Akkermansia promotes intestinal mucosal barrier damage and gut inflammation, facilitating abnormal -syn aggregation within the intestine, which can ultimately lead to systemic inflammation [89]

Gender and Genetics Studies of healthy men and women indicate that certain acquired and genetic determinants may affect total plasma homocysteine

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Quantification of the ratio of nuclear/cytosolic Nrf2 staining indicated a concentration-dependent increase in Nrf2 translocation from the cytosol to the nucleus for both NFT and DEM treatments (Fig