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Amsterdam, The Netherlands: 2010

The Wnt/-catenin pathway is downregulated in the brains of AD patients

TGF-1 also positively regulated the extracellular matrix (ECM) and led to significant up-regulation of the ECM marker proteins alpha smooth muscle actin (SMA) and zinc finger E-box-binding homeobox protein1(ZEB1) and down-regulation of E-cadherin, which in turn encouraged renal mesangial fibrosis and glomerulosclerosis[39]