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Similarly, insulin administration improved memory performance in early disease stages, mildly cognitive impaired, and mild dementia elderly cohorts, particularly in the apolipoprotein epsilon 4 (APOE4) genotype negative subgroup [66,67,68]

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Conclusions: Thymulin and thymopentin are effective anti-inflammatory modulators with direct actions on innate immune cells

In this context, nitric oxide and chemokines such as CC motif ligand 3 (CCL3), CCL4 and CCL5, which are secreted by reactive microglia, impair neuronal autophagy and countering these effects was found to be protective in disease models 33,81