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Glutamate dehydrogenase (GDH) and aspartate aminotransferase (AAT) catalyze the reversible reaction between glutamate and -ketoglutarate (-KG) before the incorporation of glutamate into the TCA cycle ( Figure 1A ) ( Figure 1 Compared to normal cells, cancer cells are characterized by the rapid proliferation of cells, followed by a highly active metabolism ( 1.1 Glutamate receptors and tumor microenvironment Cancer cells with different types of cells such as endothelial cells, fibroblasts, immune cells, and extracellular components ( The role of glutamate in the regulation of the metabolism in the TCA cycle has been amply investigated previously and reviewed ( Figure 1B ) [See references ( Figure 1 summarizes the different roles of glutamate in the cell)

The box is not just packaging

This technology has the characteristics of targeting, less toxic and side effects, and easy to combine with other methods

doi: 10.1016/j.bcp.2023.115854 33 MontaltoFIDe AmicisF

b , The extracellular gating residues in outward-open DA-bound dDAT