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"Glycine metabolism in animals and humans: implications for nutrition and health." Amino Acids, vol

ATP6AP1 KO cells exhibited an increased m compared to WT cells, which was further elevated by ACT treatment (Figs

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NAFLD is an independent risk factor for chronic kidney disease

The combination of these findings positioned NNMT as a candidate metabolic-disease and metabolic-aging research target, motivating development of selective small-molecule inhibitors including 5-Amino-1MQ