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When the intestinal barrier function is impaired, microbial products such as LPS, bacterial DNA, and peptidoglycan can enter the bloodstream and migrate to the lungs, activating local immune responses through TLRs (152154)

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Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

10.1023/A:1021779624971

Our findings provide a new mechanistic insight into the resistance of IGF-1R inhibition in which MEK1/2 activation stimulates the survival signal (Fig