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In contrast, the neural network-based models AlphaFold v.2.2.3 (AlphaFold Database Q12983) and RoseTTAFold (template structure: PDB code 2K7W) yielded predominantly disordered models without defined tertiary structure, consisting of 45 -helices that neither match the secondary structure composition determined by CD spectroscopy nor the intramolecular cross-links (Supplementary Fig