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Cancer cells harbor oncogenic mutations, leading to an increase in nutrient uptake, and altering their metabolism to support anabolic processes for cell growth and proliferation

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33,34 Because GSH is vital in detoxification and cell physiology, its depletion has been speculated to represent an important contributing factor of liver injury, and enhanced morbidity in patients with liver injury

Antioxidants (Basel) 10(2):157

PfK13 mutations leading to decreased PfK13 protein levels, impaired hemoglobin uptake and an elevated antioxidant capacity, are central to artemisinin resistance