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More research is needed to elucidate further the importance of 5mC and 5hmC in OLGs, and to understand the complex roles of DNMTs and the TET family of enzymes

Spine 1 , 1003 (2016)

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition