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Health status considerations: Generally healthy adults with physician clearance, individuals without contraindications (pregnancy, active malignancy, severe organ disease), those willing to commit to proper administration protocols and monitoring, and patients who understand the research-purposes-only status and informed consent requirements

Front Neuroenergetics 1:110 Schmidt MM, Dringen R (2010) Fumaric acid diesters deprive cultured primary astrocytes rapidly of glutathione

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254-257 For these reasons, the Panel judged that the risks/burdens of BCG outweigh its benefits for IC/BPS patients in routine clinical care situations