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Interestingly, despite the membrane localization of p35 and p39, active CDK5/p35 and CDK5/p39 complexes are also present in the cytoplasm, in addition to the membrane, which is guided by CDK5-mediated phosphorylation of p35 at S8

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.den Engelsen C., Koekkoek P.S., Gorter K.J., van den Donk M., Salom P.L., Rutten G.E

DNA constructs encoding the ribozyme may be introduced into the cell in the same manner as described above for the introduction of antisense encoding DNA

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