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Description

Bacteriophages targeting Enterococcus faecalis enhance the therapeutic efficacy of levodopa in an MPTP-induced Parkinsons disease mouse model with E

The following non-pharmacologic interventions may be used in conjunction with other therapies to optimize treatment plan

This is of particular interest, as the improper regulation of dopamine can result in a histamine response

Several inhibitors, HC067047 (TRPV4 inhibitor), Pyr3 (TRPC3 inhibitor), SKF96365 (TRPV2 inhibitor), 9-phenanthrol (TRPM4 inhibitor), JNJ-28583113 (TRPM2 inhibitor) and GsMTx-4 (Piezo1 inhibitor) successfully suppressed PMA-induced NET formation in WT BMNs and dHL-60 cells to the levels observed in XKR8-deficient cells (Fig