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Beside methionine oxidation and protein N-terminal acetylation, following cysteine modifications were considered as variable modifications: sulfinic acid, sulfonic acid N-ethylmaleimide, glutathione, disulfide (-H)

10.1186/s12943-025-02372-0 129

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A growing body of literature has highlighted the capacity of BDG to induce long-term epigenetic reprogramming in innate immune cells, termed trained immunity, which leads to an adjusted response to a subsequent challenge and to some metabolic changes, including a switch from oxidative phosphorylation to aerobic glycolysis (10, 11)

While NAD+ focuses on mitochondrial energy production and DNA repair, peptides are generally used for targeted signaling and tissue regeneration