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52,53,54 In contrast, in conditions such as chronic obstructive pulmonary disease, 55 idiopathic pulmonary fibrosis, 56 hypertension, 57 type II diabetes, 58 neurodegenerative diseases, 59 cancer, 13 and systemic inflammatory response syndrome, 60 redox regulation indirectly influences disease progression through signal transduction pathways

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It promotes the production of growth factors and extracellular matrix proteins, which are essential for skin regeneration and collagen formation

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The apolipoprotein E 4 (APOE4) allele confers the highest risk for AD, whereas APOE2 acts protectively