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Loss of the blue color, cloudiness, or unusual viscosity changes are the primary visual indicators of degradation

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Additionally, longitudinal studies examining the immediate, intermediate and long-term effects of elevated Mn exposure on children and adults are needed to identify age- and sex-specific susceptibilities, and potential biological, psychological and cognitive biomarkers

Expert Opin Drug Metab Toxicol 5:10231038 Nicholson JK, Lindon JC, Holmes E (1999) Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

Glutamine-target strategies including depletion of systemic glutamine and application of glutamine uptake inhibitors, glutamine antagonists/analogues, and glutaminase inhibitors