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To model a dataset with imbalanced classes, patients were split into two groups of 7000 and 3000 patients, respectively, where binary variables were identical within groups by a random selection of 0's and 1's

Getting regular exercise, practicing good sleep, reducing stress, maintaining a healthy diet, and taking medications as needed can all help to reduce the severity of flare-ups

6 Furthermore, patients who develop exacerbations while on LAMA/LABA therapy may be escalated to LABA/LAMA/ICS therapy

Instead, no significant reduction of the survival fraction was observed upon 2DG treatment in combination with lower doses of IR ( Figures S4EI )

Cavalie M, Ezzedine K, Fontas E, Montaudi H, Castela E, Bahadoran P, et al