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TRPV1 has been identified as the primary mechanism behind cysteine oxidation in response to redox changes, but this has yet to be fully elucidated biochemically ( 2+ levels, apoptosis, oxidative stress, etc

Importantly, the longevity effect of caloric restriction (CR)which is discussed in the Supplementary Section Beyond Geneticswas shown to be dependent on the proper functioning of autophagy (Jia and Levine, 2007)