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Thirst is the most obvious sign

Quali effetti collaterali sono noti

Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs

The observed accumulation of LDH and ALT in vascular medium supernatants compared to supernatants from the static hepatic chamber could be attributed to increased permeability upon cytotoxicity and subsequent accumulation of toxicity markers in the vascular perfusion (Supplementary Fig

That matters most when you are already worn down and drinking water is not catching you up fast enough