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Glutathione peroxidase (GPX)

In the context of this discussion, haptenation of skin proteins was defined as the key biological event in skin sensitization, and Aleksic and Gerberick developed a peptide reactivity assay to quantify the covalent binding of directly reactive and metabolite-generated haptens to lysine and cysteine amino acids [86,87,88,89]

Specifically, Cd is known to impede cellular antioxidant defence systems through the inhibition, depletion and/or replacement of essential elements, indirectly leading to oxidative stress [95]