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The discussion of oligomerization (page 3-8) is described elsewhere in detail (including cited references) and can be somewhat summarize here

In the last few years, Citizen Science projects proved to be another source to gather cephalopod egg presence in the field

Between 2 and 12% of patients receiving high-dose MTX therapy may get acute kidney injury, mostly as a result of crystal nephropathy caused by MTX and its metabolite, 7-OH-MTX